Immune cells in breast cancer offer potential therapeutic target

A new report, led by researchers at the University of Pennsylvania, filled in crucial details about the connection between MDSCs and Blocking the MDSCs themselves reduced growth and in a mouse model of TNBC. The findings appeared in “We’re excited because we think our findings could make a big difference for triple-negative breast patients,” said “Not only can deltaNp63 be used as a biomarker to help personalize treatment regimens, but targeting it may also provide an additive treatment for triple-negative breast cancer, in addition to and ” Earlier studies showed that increased levels of deltaNp63 were linked with breast initiation. They used multiple mouse models and tissue transplants to see how manipulating the level of deltaNp63 affected the behavior of cancer, and they found lower levels corresponded with less to distant tissues. In addition, knocking down levels of deltaNp63 made the much less aggressive, and it reduced numbers of MDSCs recruited to the tumor but not other immune cell types. The research team used small molecules to inhibit CXCL2 and CCL22 in human TNBC cell lines as well as in a mouse model of TNBC, a blockade that significantly reduced levels of MDSCs moving to the and that substantially lowered signs of metastasis.

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